Full dynamics of changes in the regulatory tonus of both the parasympathetic and sympathetic nervous systems. In USA for non-medical use only

Real-time HRV monitoring system

Normative database included Software provides analysis of HRV test results based on a large population normative database. Interpretation of test results included in report for all types of tests!

HRV Live! provides the means for continuous real-time monitoring and recording of the autonomic nervous system’s regulatory function. It is based on the standard short-term HRV analysis of heart rate (HR) data obtained from either an ECG recorder or a pulse wave sensor. HRV Live! provides detailed analysis of the recorded HRV data. The HRV Live! shows the full dynamics of change in the regulatory tonus of both the sympathetic and parasympathetic nervous systems and autonomic balance over a prolonged period of time.

Standard compliance

The Heart Rhythm Scanner software was developed according to the standards and mathematical procedures for short-term HRV analysis set forth by:

• The European Society of Cardiology
• The North American Society of Pacing and Electrophysiology

HRV Live! software allows for unlimited monitoring and recording of raw signal (ECG or pulse wave), heart rate and HRV data. Later these records can be reviewed and edited. The software allows for creating unlimited number of event markers during data recording. Later those markers can be reviewed and multiple HRV profiles (single set of HRV data calculated on preset time interval - typically 5 minutes) associated with those markers derived from data recording. Unlimited number of special data picks can be created to derive similar HRV profiles. A special comparison report can be generated and printed out showing all details on all available HRV profiles showing absolute HRV readings as well as their respective % of change relative to preselected reference point. All data are displayed in both numerical and graphical formats.

HRVLive! Software patch

Features

• Assessment of sympathetic and parasympathetic tonus
• Compliance with the Standards of short-term HRV analysis
• Real-time continuous monitoring of changes in HRV parameters
• Ability to create time markers during monitoring process
• Ability to detect sudden changes in autonomic balance
• HRV data comparison to the population norms
• Autonomic balance zone diagram for continued comparison
• Various HRV session report capabilities: graphs, bars, spectrum, etc.
• Multiple comparisons of data associated with time markers
• True Windows Me/2000/XP physiological monitoring software
• Easy software installation and automatic detection of connected device

Key benefits

• Assessment of sympathetic and parasympathetic tonus
• Compliance with the Standards of short-term HRV analysis
• Real-time continuous monitoring of changes in HRV parameters
• Ability to create time markers during monitoring process
• Ability to detect sudden changes in autonomic balance
• HRV data comparison to the population norms
• Autonomic balance zone diagram for continued comparison
• Various HRV session report capabilities: graphs, bars, spectrum, etc.
• Import/Export data in software specific format
• Multiple comparisons of data associated with time markers
• True Windows Me/2000/XP physiological monitoring software
• Easy software installation and automatic detection of connected device

Featured screenshots:

Assessment of sympathetic and parasympathetic tonus (Example of LF/HF changes in real-time shown in left top section of the screenshot.)	Real-time continuous monitoring of changes in HRV parameters (Real-time changes of LF, HF, LF/HF, SDNN, Total Power etc.)
Ability to detect sudden changes in autonomic balance (A real-time sympathetic increase is clearly seen in a left-top of the screenshot.)	HRV data comparison to the population norms (Green zones indicate population norms. HRV Profile has HRV norms in right column.)
Autonomic balance zone diagram for continued comparison	Multiple comparisons of data associated with time markers

Practical use

The HRV Live is the world only professional tool designed to do continuous monitoring of the autonomic function by means of performing repetitive heart rate variability (HRV) analysis in real-time.

There is no other tool available providing capability to get HRV parameters over and over again in real-time to observe full dynamics of changes in the autonomic regulation.

Many professionals can use the HRV Live in their daily practice to enhance their health assessment techniques and optimize their treatment procedures.

Here are just few examples:

1. Clinical researchers may use the HRV Live to measure effect of their investigational procedures or substances on autonomic function – how strong the effect is, how quickly it appears and how long it sustains.

The autonomic nervous system is a complex regulatory mechanism in a human body. It reacts to any process going in the body and acts properly to adapt the body to changing environment. For instance pain causes stress response in the body, which is a typical pattern of the autonomic function. By doing certain treatment procedure or administering a treatment substance to relieve pain we alter the autonomic function. HRV Live quickly picks changes happening in this function and gives distinctive unbiased quantitative picture of this effect.

2. Healthcare practitioners may find the HRV Live as a great help in testing substances causing allergy.

There are many alternative healthcare practitioners using special methods like muscle testing to find out if certain allergens cause human body to respond to their application. This procedure helps to find possible food or other types of allergies. HRV Live can be used instead of muscle testing because it measures changes in HRV parameters as a reflection of reactions of the autonomic nervous system to such applications of known allergens. Sensible allergens cause stress response of the body and HRV Live picks it in real-time. Apply allergens one after another and watch the autonomic response in an objective placebo-free way.

3. Healthcare practitioners may use the HRV Live to find optimal doses of their treatment.

Alternative healthcare practitioners may monitor the autonomic function in real-time while giving their clients increasing doses of their treatment substances or procedures. With an assumption that the treatment has quick effect on the autonomic function the HRV Live may help to find out what optimal individual dose of the treatment causes sufficient expected effect on the body.

Important! There are important requirements needed to be followed when using the HRV Live. Patients should avoid eating within 2 hours before testing, having any stimulating drinks like coffee, having vigorous exercises or experiencing significant emotional events. Any temporary sickness like flu is also a reason to refrain from testing. 

• Heart Rhythm Scanner software
• Choice of hardware (Details below. PPG Bluetooth Not shown)

Electrocardiograph (ECG)
ECG BC-4000 USB connectivity (wired)	ECG BC-5000 Bluetooth connectivity (wireless)
Weight: 2.0 Oz / 56 g Sample rate: up to 1024 Hz Dimension: 2.75 x 1 x 0.625 inches 70 x 25 x 15 мм Connection: USB Additional info: Resolution < 1 µV/Bit ECG, 14 Bit Frequency Response - 0.2 – 150 Hz	Weight: 2.4 Oz – 68 g Sample rate: Up to 500 Hz Dimension: 2.75 x 2.19 x 0.625 inches 70 x 55 x 20 мм Connection: Bluetooth Additional info: Resolution < 5 µV/Bit ECG, 17 Bit Power consumption 100mA (rechargeable battery) Power consumption 80mA (alkaline battery) Bluetooth range: up to 10 meters
Electrocardiograph (ECG) is a tracing, which represents the heart electrical activity derived by amplifying minutely small electrical impulses generated by the heart. The electrical impulses generated in the heart muscle are recorded and transmitted to the electrocardiograph by electrodes or leads attached to the body by small disposable metal plates. The moistened plates are attached to the arms, legs, and cardiac areas. ECG is a widely accepted and important diagnostic tool. ECG is used in some routine medical examinations when a heart disorder is present or suspected. ECG helps diagnose the damage that may have been inflicted on the heart muscle as a result of coronary occlusion, rheumatic fever, the presence of abnormal rhythms, and the effect of drugs. Moreover, ECG recordings provide information on the current fitness status of the heart as well as reflect HRV as a result of ANS regulatory balance.

Photoplethysmographs (PPGs)
PPG BC-1000 USB connectivity (wired)	PPG BC 1200 USB connectivity (wired)
Photoplethysmograph (PPG) was developed in the 1960's and 1970's by psychophysiology researchers. The instrument is used for assessment of peripheral blood flow to the extremities. When the client is stressed their blood vessels constrict (less blood flow in fingers). Photoplethysmograph is based upon the premise that all living tissue and blood have different light-absorbing properties. PPG works by placing an individual finger between two parts of a transducer consisting of a light source and a photocell (which converts light to electrical energy). A beam of infrared light is projected toward the photocell. The blood in the finger scatters light in the infrared range, and the amount of light reaching the cell is inversely related to the amount of blood in the finger. Hence, when blood vessels in the finger dilate, the increased blood flow allows less light to reach the photocell, when blood vessels constrict, blood flow is decreased and increased light reaches the photocell. Pulse volume measurements are related beat-to-beat variations in the force of blood flow. Phasic changes made on a beat-to-beat basis, are called pulse volume measurements and are related to beat variations in the force of blood flow. These beat-to-beat changes in peripheral blood flow reflect ANS regulatory activity and can be used for the purpose of evaluation of sympathetic activity or stress. (“Measuring Stress” by S. Cohen, R. Kessler and L. U. Gordon, 1995)

Using device right

	Biocom 4000 ECG recorder has three large non-disposable dry ECG electrodes to be placed on wrists of both hands secured with elastic wristbands.
	Typically the PPG BC-2000 should be placed on earlobe. In some cases when earlobe placement does not give good pulse wave signal the PPG BC-2000 can be placed on a finger.
	The PPG BC-1000 is designed for use on finger tip
	Typically the PPG BC 1200 should be placed on earlobe In some cases when earlobe placement does not give good pulse wave signal the ear-clip can be placed on a finger.

• CPU Pentium 4, 1.6 GHz (or equivalent)
• 1 Gb of RAM
• Video card with at least 1024x768 and High-Color resolution
• 1 Gb of free hard disk space
• CD ROM drive
• One available USB port, version 1.1 or higher
• Windows 2000/XP/Vista or 7 Operating system

HRV Live 1.0 Manual